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Post: Hello Andrew ! Many thanks for your prompt reply. I understand now that PT100 sensor can not be connected to ADC Pi Plus directly. Today, I found the temperature transmitter in Amazon USA. "Uxcell a13032900ux0675 PT100 Temperature Sensor Transmitter 0-150 Degree Output 0-5 VDC, 1.69" Width, 1.57" Length Product description Product Name : Temperature Transmitter; Model : SBWZ; Material : Plastic, Type : PT100; Temperature Range : 0-150 Celsius Degree; Output Voltage : 0-5V DC, Power Supply : 24V DC; Rated Load : 250 Ohm; Precision : 0. 2%, Size : 4 x 4. 3 x 2cm/1. 6" x 1. 7" x 0. 8"(L*W*T); Color : Blue." I think this product is suitable to connect the PT100, an output is 0-5VDC proportional to the temperature of PT100 sensor. I need your advice for: 1. Separated power supply 24DC is prepared for the transmitter. Output terminal of transducer is 0-5VDC. Is 0V of separated power supply connected to ADC Pi Plus ? Is max. 5DC from transducer will be connected to input 1 at ADC Pi Plus ? 2. To measure the temperature with good accuracy, I2C address selection will be 0x68 and 0x69 as default ? Is it correct ? 3. 5xPT100 will be connected via above temperature transmitters. ADC Pi Plus has 8 x input. How the connection of unused 3 input ? just open or need jumper wire ? 4. In knowledge base, there are several application as demo. I will try to study and one of demo will be modified. However, I am quite beginner of Python, Could you kindly recommend one of demo to measure 5 input with 0-5VDC ? Short instruction is appreciated. 5. Is there any changes to 5 input 0-5VDC for ADC Pi Plus ? I appreciate your kind support Hideaki Hashikura